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MPNS COST Action 1205
Advances in Optofluidics: Integration of Optical Control and Photonics with Microfluidics

European Cooperation in Science and Technology
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ISMN-CNR

ISMN-CNR, Area della Ricerca di Bologna, Italy

Project Title:

Microfluidic devices for generating gradients and flat patterns of different cues on the surfaces

Abstract:

The idea of this activity is to exploit the long standing experience of the ISMN-CNR group in the field of microfluidics, dewetting and micro- and nano-patterning for functionalizing the surfaces in order to have the cues distributed, not in an homogeneus way, but according to gradient profiles. This issue is central to several different applications lab-on-a-chip:

  1. gradients of different hydrophobicity can be a powerfull tool for guiding droplets of liquids onto active surfaces, thus achieving a delivery of the analyte solutions on the active areas of the device.
  2. gradients of molecules inducing cell adhesion can be used for directing the migration and differentiation of different cell types thus achieving an accurate both cell guidance and sorting (disease affected cells vs healthy ones) onto technologically relevant surfaces

Flat patterns based on the lithographic processes in combination with dewetting processes will be as well fabricated; in particular Lithographically Controlled Wetting (LCW) will be used to locally position anchoring points for molecules that will be required for the integrated device (active proteins or grafting sites).


WG1: Integrated Microfluidic Photonics

Project leaders

Francesco Valle

People involved in the project

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