Gazi University, Turkey
The development of a new analysis platform based on the surface enhanced Raman spectroscopy and measurement of blood sugar levels
Our aim is to construct an optofluidic surface enhanced Raman spectroscopy (SERS) device that uses nanostructure-embedded based microfluidic system to provide SERS-active sites. The advantages of microelectromechanical Systems (MEMS)-based products and production processes are the use of small amounts of reactive, improved sensitivity and faster analysis times and low power consumption of portable devices, with appropriate for point-of-care diagnosis. In our study, a microfluidic chip containing SERS active substrate will be constructed using the surface micromachining technique for the determination of glucose. Proposed approach is going to be a pioneering study in molecular recognition system and the rapid detection of glucose has considerable importance in national economy.
We propose a multidisciplinary project, which aims at showing the feasibility of a new method for the detection of glucose by means of coupling the microfluidcs to Raman spectroscopy. For this aim, proposed assay platform which is capable of detecting the attachment of glucose will be studied thoroughly for different structures of gold nanoparticle and geometrical designs that provide SERS signal amplification. The design, preparation and surface modification of nanoparticles which could be used for SERS application will give an opportunity of effective isolation of target glucose from complex blood sample and SERS signal will also be obtained from a microfluidic chip which will be developed through this project. In the scope of the proposed project, a microfluidic chip containing SERS active surface will be developed.
The financial support was provided by The Scientific and Technological Research Council of Turkey; (TUBITAK)
Project no: 111T983
WG3: Materials (soft, bio and nano) and technologies for optofluidic devices